The number of guns and rounds that you can hunt with are innumerable. However, I have a soft spot for the .308. It does fine on deer, and having a military background, I spent a lot of time with M-14's and the venerable 7.62mm cartridge. Nostalgia aside, the 308 is one of the most popular cartridges in America. I enjoy using a Browning lever 308 with a Leupold vari-x II scope; this is a pretty good all around big game cartridge for the northeast. I also use a Winchester 94 in 30-30. Partially for reasons of nostalgia, I grew up in Connecticut shooting on the Winchester ranges in New Haven in smallbore programs. That notwithstanding, the 30-30 is not as good a round as the 308, but with the new Federal Leverevolution ammo it is a better cartridge than it used to be. I have mine topped with a Lyman iron sight, (another harkening back to my Connecticut days). At any rate, a hunter's marksmanship ability with his or her rifle is much more important than the specific caliber.