I used a 243 for a lot of years never had a deer run more then 10 yards. I shot deer with the 3006 and 270 as well and see no difference. A well placed shot will ALWAYS be a kill, if you tell me any different I would tell you, you didn't hit the deer where you thought you hit it. People in our hunting party take them out west every year for long range shots due to its flat traveling, fast moving bullet. Out west we hunt mulies, whitetail, pronghorn, and preditors. So its not just small game animals. You tell me any difference I would disagree.