The powder I found that generates the best hunting velocities is Hodgdon H110. This goes for pistol or rifle.
The only problem with H110 is that it is prone to creating a major $%!^-storm at the end of the muzzle. When I was dabbling in this, a buddy recommended H110 as THE powder for 44 Mag. He warned me: when you go to the range, everyone will know you're shooting H110. He was right. Zowie!!! Lots of flash. Lots of concussion. If you show up at an indoor range with this stuff, you'll have every head turning. The first time I took it to my outdoor range, the RSO came running over. He thought I'd blown up the gun. It was just a 10%-off-MAX starter load.
Nowadays, I've given up on 44 Mag for deer hunting. When I use my Ruger Blackhawk hand-cannon, I'm shooting TiteGroup, because it is cleaner burning than Unique.