Sounds to me like the deer probably just changed their patterns. Could be from the hunting pressure, but just as likely that it was due to changing food preferences, prevailing winds, the rut, or maybe just deer being deer. One thing is for certain, they went somewhere and there will be sign where they are. The key is finding that fresh sign and hunting there. You gotta stay on the move, just like the deer.
Hunting takes place before you climb into your stand. Everything after that is just shooting. TM